Virus-Like Particle Bound Magnetic Particles As Reagents For Immunodiagnostics
Virus-Like Particle Bound Magnetic Particles As Reagents For Immunodiagnostics
Description
Abstract:
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- Described herein are virus-like particles (VLPs) that were generated to present the viral glycoprotein antigens on their surface, coupled to magnetic fluorescent microspheres to create VLP-conjugated microspheres (VCMs) and methods of making them. These VCMs were stable when lyophilized and stored at 37.degree. C. and able to detect antibodies in non-human primate (NHP) and human clinical sera at dilutions of 1.times.10.sup.5 and 1.times.10.sup.4, respectively. Methods are also disclosed for detecting an immune response using VCMs.
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Issue/Publication date:
| 06/13/2019 |
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