Modulation Of Replicative Fitness By Deoptimization Of Synonymous Codons
Modulation Of Replicative Fitness By Deoptimization Of Synonymous Codons
Description
Abstract:
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- Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.
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Issue/Publication date:
09/30/2014
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