Inhibition Of Hif-2Alpha Heterodimerization With Hif1Beta (ARNT)
Inhibition Of Hif-2Alpha Heterodimerization With Hif1Beta (ARNT)
Description
Abstract:
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- Provided is a method of inhibiting heterodimerization of HIF-2.alpha. to HIF1.beta. (ARNT) comprising binding certain small molecules to the HIF-2.alpha. PAS-B domain cavity but not to HIF1.alpha. and inhibiting HIF-2.alpha. heterodimerization to HIF1.beta. (ARNT) but not inhibiting HIF1.alpha. heterodimerization to HIF1.beta. (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2.alpha. heterodimerization inhibitors and also simply as certain small molecules.
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Issue/Publication date:
| 09/01/2016 |
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