Polyionic Papilloma Virus-Like Particle (Vlp) Vaccines
Polyionic Papilloma Virus-Like Particle (Vlp) Vaccines
Description
Abstract:
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- The present invention relates to the field of vaccines. In particular, the present invention provides compositions and methods relating to virus-like particle (VLP) vaccines. In one embodiment, a chimeric papillomavirus virus-like particle (VLP) comprises the L1 protein, wherein the HI loop of the L1 protein comprises negatively charged amino acids. In a more specific embodiment, a chimeric bovine papillomavirus VLP comprises the L1 protein, wherein the amino acid sequence EEEEEEEEC is inserted into the HI loop of the L1 protein.
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Issue/Publication date:
| 02/28/2017 |
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